Search results for "Pyrimidine metabolism"
showing 4 items of 4 documents
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma
2021
Simple Summary Individual patients with liver cancer have a highly variable clinical course. Hence, there is an urgent need to identify new prognostic markers to determine prognosis and select specific therapies. Expression of two key enzymes in pyrimidine synthesis was analyzed in a large, well-characterized cohort of patients with liver cancer. Dysregulated expression of these enzymes was associated with shorter survival of the patients. A combined score of both markers was found to be a statistically independent prognostic marker. Abstract Patients with hepatocellular carcinoma (HCC) have a highly variable clinical course. Therefore, there is an urgent need to identify new prognostic mar…
Leflunomide, a reversible inhibitor of pyrimidine biosynthesis?
1995
Elucidating the catalytic reaction mechanism of orotate phosphoribosyltransferase by means of X-ray crystallography and computational simulations
2020
15 p.-8 fig.-2 tab.1 graph. abst.+ 8 fig. supl.-1 tab. supl.
Nucleotide, Nucleoside, Purine, Pyrimidine, Pteridine
1952
Die Organe erwachsener Tiere enthalten zumeist mehr Ribonucleotide als Desoxyribonucleotide (Tabelle 159). Der Quotient RN : DRN ist in fetalen Geweben kleiner als in erwachsenen. J. Geschwind und C. H. Li fanden ihn in der fetalen Rattenleber zu 0,9, in der Leber neugeborener Ratten zu 1,9 und in der Leber 40 Tage alter Ratten zu 2,8.